Powder multivitamin: why 29 actives (and not 50)
Why base One contains 29 compounds and not 50 or 80. Bioavailable forms, clinical dosages, formulated in Switzerland according to orthomolecular principles. The complete brief.
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29 bioactive compounds |
100 % bioactive forms |
580 mg -Vit. C dose / sachet of 6 g |
Swiss Made manufacturing |
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1. Why Base One exists: a response to measurable deficits
The contemporary industrial diet, even carefully balanced and nutritious, does not reproduce the micronutritional density of a 1940 peasant day. This observation is not hypothetical; it is calculated food by food based on the CIQUAL 2020 table and corrected by published decline coefficients (Mayer 1997 ; Mayer et al. 2022 ; Fan et al. 2008).
Best dietary day 2025vs peasant day 1940 |
Observed deficits (CIQUAL 2020)Magnesium −35 % Zinc −42 % Selenium −42 % Vitamin B9 −40 % Vitamin B6 −39 % B12 −24 % Copper −72 % Calcium −53 % Vitamin B1 −43 % |
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No nutrient analyzed is better covered in 2025 than in 1940.
Smart supplementation is a rational response.
2. What distinguishes Base One from 95% of the market
a. Bioactive forms and precursors for prolonged effect
The vast majority of multivitamins on the market contain inexpensive synthetic precursors requiring several enzymatic conversions whose yield varies by individual.
Base One selects forms usable by the cell and extends activity with appropriate precursors.
Base One does not stimulate the hypothalamic-pituitary-adrenal axis. It nourishes cellular energy production via the Krebs cycle and the mitochondrial respiratory chain. The perceived effect is a stable base energy, without peaks or drops, in contrast to stimulants that deplete hormonal reserves and ultimately aggravate deficiencies in B vitamins and vitamin C.
b. Without absorption antagonisms
Iron, zinc, and copper compete for the same intestinal transporters (DMT1). Administered simultaneously, they mutually inhibit up to 40–80% (PubMed 11509108). Base One deliberately excludes iron and copper from the formula by biochemical rigor. Each retained molecule is compatible with the others.
c. Powder: 12 capsules of active matter in one sachet
A standard capsule contains ≈ 500 mg of powder. One Base One sachet of 6 g is equivalent to 12 capsules in terms of nutritional matter, allowing clinically relevant dosages impossible to achieve in tablet form.
3. Body signals: common symptoms linked to targeted deficiencies
These symptoms are often underestimated or attributed to other causes. They constitute concrete entry points for store advice.
| Symptoms | Nutrients involved in Base One |
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| Persistent fatigue | Magnesium, B1, B2, B3, B5, B6, B12, Iron (indirect via Vitamin C), Potassium |
| Muscle cramps | Magnesium, Potassium, Vitamin B1, B6 |
| Foggy mind, lack of concentration | B6 (neurotransmitters), B9, B12, Iodine, Zinc, Selenium (thyroid), Magnesium |
| Anxiety, irritability, fragmented sleep | Magnesium, Glycine, L-Glutamine (GABA), B6, Inositol, Vitamin C |
| Thinning hair, brittle nails | Biotin (B8), Zinc, Selenium, Vitamin C, Glycine |
| Dull skin, slow healing | Vitamin C (collagen), Zinc, Beta-carotene (Vit. A), Glycine |
| Sensitivity to infections, low immunity | Zinc, Selenium, Vitamin C, B9, B12, Beta-carotene |
| Unstable blood sugar | Chromium, Magnesium, Inositol, Vitamins C, B3 and B5 |
| Blinking eyelids, muscle tension | Magnesium (classic sign of subclinical deficiency) |
| Subclinical thyroid disorders | Iodine, Zinc, Selenium (conversion T4→T3) |
| Lack of deep energy | B1, B2, B3, B5 (coenzymes of the Krebs cycle), Magnesium (cofactor ATP), Malic acid (direct intermediate of the Krebs cycle), Potassium (cellular membrane gradient) |
| Chronic stress, adrenal exhaustion | Vitamin C (each molecule of adrenaline consumes a molecule of vitamin C; adrenal reserves collapse under chronic stress if intake is insufficient), B5 (stimulation of the adrenal glands), B6 (synthesis of catecholamines) |
| Sleep disorders, difficulty falling asleep | Glycine (documented improvement in sleep latency and quality), L-Glutamine (precursor of GABA), Magnesium (Gabaergic, neuromuscular relaxation), Inositol (serotonergic modulation), B6-P5P (cofactor of glutamate decarboxylase, synthesis of GABA) |
| Intestinal permeability, digestive discomfort | L-Glutamine (fuel for enterocytes, reinforcement of tight junctions, reduction of mucosal inflammation), Glycine (gastric cytoprotection, stimulation of mucus secretion), Zinc, Beta-carotene (epithelial differentiation) |
| Slow muscle recovery, catabolism | L-Glutamine (counters exercise-induced and intense physical activity muscle catabolism), Glycine (dominant component of type I collagen), Magnesium, Potassium |
| Inefficient liver detoxification (overloaded liver) | Glycine (primary amino acid in hepatic conjugation, phase II detoxification pathway), L-Glutamine (precursor of glutathione with cysteine), Vitamin C (regenerates oxidized glutathione into reduced glutathione), Malic acid (gentle chelation of aluminum, supports hepatic mitochondrial flux) |
4. Manufacturing and traceability: Swiss Made without compromise
Manufactured in SwitzerlandSwiss quality controls (OSAV), standards superior to EU regulations. |
No controversial excipientsNo titanium dioxide (E171), no artificial sweeteners, no unnecessary colorants. |
Complete scientific dossierMolecule-by-molecule argumentation available for healthcare professionals, with PubMed references. |
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Base One is formulated by David Giovenco, a researcher in micronutrition, teacher in orthomolecular medicine, therapist, and President of the International Francophone Academy of Orthomolecular and Integrative Medicine. This product is the result of 9 years of research and 16 years of clinical practice in developing formulations for Swiss, European, and global brands.
5. In summary
Real bioavailability: 29 compounds in their bioactive form, assimilable, with prolonged action thanks to various precursors.
Consistent formula without antagonisms: the selected molecules complement each other and do not mutually cancel out, unlike most multivitamins on the market.
Clinically relevant dosages: Calibrated for cell optimization, not just deficiency prevention.
Swiss Made, clean, verifiable: manufactured in Switzerland, without E171, without aspartame, with a molecule-by-molecule scientific dossier accessible to all healthcare professionals.
Nine years of research, an uncompromising formulation: Base One was born from the realization that no existing formula combined biochemical rigor, bioactive forms, intra-formula synergies, and purity of excipients.
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nuho.ch • support@nuho.ch NUHO Health SA, Rue des Usines 44, 2000 Neuchâtel, Switzerland |
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